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Nascent mutant Huntingtin exon 1 chains do not stall on ribosomes during translation but aggregates do recruit machinery involved in ribosome quality control and RNA.
Ormsby, Angelique R; Cox, Dezerae; Daly, James; Priest, David; Hinde, Elizabeth; Hatters, Danny M.
Afiliación
  • Ormsby AR; Department of Biochemistry and Molecular Biology; and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, VIC, Australia.
  • Cox D; Department of Biochemistry and Molecular Biology; and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, VIC, Australia.
  • Daly J; Department of Biochemistry and Molecular Biology; and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, VIC, Australia.
  • Priest D; Department of Biochemistry and Molecular Biology; and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, VIC, Australia.
  • Hinde E; Department of Biochemistry and Molecular Biology; and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, VIC, Australia.
  • Hatters DM; Department of Biochemistry and Molecular Biology; and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, VIC, Australia.
PLoS One ; 15(7): e0233583, 2020.
Article en En | MEDLINE | ID: mdl-32735619
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Extensión de la Cadena Peptídica de Translación / Ribosomas / ARN Mensajero / Exones / Agregado de Proteínas / Proteína Huntingtina Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2020 Tipo del documento: Article País de afiliación: Australia
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Extensión de la Cadena Peptídica de Translación / Ribosomas / ARN Mensajero / Exones / Agregado de Proteínas / Proteína Huntingtina Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2020 Tipo del documento: Article País de afiliación: Australia