A comprehensive review of therapeutic approaches available for the treatment of cholera.
J Pharm Pharmacol
; 72(12): 1715-1731, 2020 Dec.
Article
en En
| MEDLINE
| ID: mdl-32737883
ABSTRACT
OBJECTIVES:
The oral rehydration solution is the most efficient method to treat cholera; however, it does not interfere in the action mechanism of the main virulence factor produced by Vibrio cholerae, the cholera toxin (CT), and this disease still stands out as a problem for human health worldwide. This review aimed to describe therapeutic alternatives available in the literature, especially those related to the search for molecules acting upon the physiopathology of cholera. KEYFINDINGS:
New molecules have offered a protection effect against diarrhoea induced by CT or even by infection from V. cholerae. The receptor regulator cystic fibrosis channel transmembrane (CFTR), monosialoganglioside (GM1), enkephalinase, AMP-activated protein kinase (AMPK), inhibitors of expression of virulence factors and activators of ADP-ribosylarginine hydrolase are the main therapeutic targets studied. Many of these molecules or extracts still present unclear action mechanisms.CONCLUSIONS:
Knowing therapeutic alternatives and their molecular mechanisms for the treatment of cholera could guide us to develop a new drug that could be used in combination with the rehydration solution.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
3_ND
Problema de salud:
3_cholera
/
3_diarrhea
/
3_neglected_diseases
Asunto principal:
Vibrio cholerae
/
Cólera
/
Antibacterianos
Tipo de estudio:
Diagnostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Pharm Pharmacol
Año:
2020
Tipo del documento:
Article
País de afiliación:
Brasil