Highly stereocontrolled total synthesis of secodolastane diterpenoid isolinearol.
Org Biomol Chem
; 18(37): 7316-7320, 2020 09 30.
Article
en En
| MEDLINE
| ID: mdl-32761027
ABSTRACT
The first asymmetric total synthesis of isolinearol has been achieved with high stereoselectively. The synthetic method includes enatio- and diastereoselective reductive desymmetrization, stereocontrolled introduction of the methallyl group, regio- and stereocontrolled allylation and introduction of the side chain carbonyl group using olefin cross-metathesis with a pinacol vinyl boronic ester.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Org Biomol Chem
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2020
Tipo del documento:
Article