Glycyl-l-glutamine attenuates NPY-induced hyperphagia via the melanocortin system.
Neurosci Lett
; 736: 135303, 2020 09 25.
Article
en En
| MEDLINE
| ID: mdl-32800923
ABSTRACT
This study aimed to determine whether glycyl-l-glutamine (Gly-Gln; ß-endorphin (30-31)), a non-opioid peptide derived from ß-endorphin processing, modulates neuropeptide Y (NPY)-induced feeding and hypothalamic mRNA expression of peptide hormones in male broiler chicks. Intracerebroventricular injection of NPY (235 pmol) generated a hyperphagic response in ad libitum chicks within 30 min. Co-administration of Gly-Gln (100 nmol) attenuated this response, inducing a 30 % decrease. This was not attributable to Gly-Gln hydrolysis because co-administration of glycine (Gly) and glutamine (Gln) had no effect on NPY-induced hyperphagia. Gly-Gln injected alone also showed no effect. The hypothalamic pro-opiomelanocortin mRNA expression in the co-injection group was significantly higher than that in the NPY alone group. These data indicate that endogenous Gly-Gln may contribute to regulate feeding behavior via the central melanocortin system in chicks and acts as a counter regulator of the neural activity in energy metabolism.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neuropéptido Y
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Proopiomelanocortina
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Hiperfagia
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Dipéptidos
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Ingestión de Alimentos
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Hipotálamo
Límite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Año:
2020
Tipo del documento:
Article