Temocillin dosage adjustment in a preterm infant with severe renal disease: a case report.
J Antimicrob Chemother
; 75(12): 3652-3655, 2020 12 01.
Article
en En
| MEDLINE
| ID: mdl-32814946
ABSTRACT
BACKGROUND:
Temocillin is a carboxypenicillin antibiotic indicated in complicated urinary tract infections due to susceptible ESBL-producing Enterobacteriaceae. While temocillin therapeutic schemes for adult patients with normal or impaired renal function are evidence based, little is known in paediatric populations.OBJECTIVES:
We report herein the management of temocillin treatment in a preterm infant with end-stage renal disease. PATIENTS ANDMETHODS:
The patient was a 7-month-old preterm infant born at 35 weeks gestation and treated by temocillin for 10 days for a bacteraemic urinary tract infection due to a susceptible ESBL-producing Enterobacter cloacae complex strain. Temocillin was administered by continuous infusion using a loading dose of 25 mg followed by a maintenance dose of 70 mg daily. Determination of MIC and temocillin plasma and urinary concentration was performed.RESULTS:
Clinical improvement was observed 24 h after the initiation of temocillin treatment. Temocillin concentrations ranged between 21.6 and 35.5 mg/L in urine between the first and the sixth day of treatment and between 47.0 and 61.8 mg/L in plasma after 6 and 10 days of treatment, respectively. Temocillin concentrations were found to be above the determined MIC of 6 mg/L. From the measured concentrations, we can postulate that 100%fT>MIC was achieved in urine and at least equal to 40% in plasma.CONCLUSIONS:
Temocillin dosing adjustment performed in the present reported case allowed safe and effective treatment. The strategy described herein could be used as a basis for further clinical studies relative to temocillin use in a paediatric population with renal impairment.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
3_ND
Problema de salud:
3_neglected_diseases
/
3_zoonosis
Asunto principal:
Penicilinas
/
Recien Nacido Prematuro
Límite:
Humans
/
Infant
Idioma:
En
Revista:
J Antimicrob Chemother
Año:
2020
Tipo del documento:
Article
País de afiliación:
Francia