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First-in-human imaging and kinetic analysis of vesicular acetylcholine transporter density in the heart using [18F]FEOBV PET.
Saint-Georges, Zacharie; Zayed, Vanessa K; Dinelle, Katie; Cassidy, Clifford; Soucy, Jean-Paul; Massarweh, Gassan; Rotstein, Benjamin; Nery, Pablo B; Guimond, Synthia; deKemp, Robert; Tuominen, Lauri.
Afiliación
  • Saint-Georges Z; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada. zacharie.saint-georges@uottawa.ca.
  • Zayed VK; The Royal's Institute of Mental Health Research, Ottawa, ON, Canada. zacharie.saint-georges@uottawa.ca.
  • Dinelle K; The Royal's Institute of Mental Health Research, Ottawa, ON, Canada.
  • Cassidy C; Brain Imaging Centre, The Royal's Institute of Mental Health Research, Ottawa, ON, Canada.
  • Soucy JP; The Royal's Institute of Mental Health Research, Ottawa, ON, Canada.
  • Massarweh G; Montreal Neurological Institute, McGill University, Montreal, QC, Canada.
  • Rotstein B; Montreal Neurological Institute, McGill University, Montreal, QC, Canada.
  • Nery PB; Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON, Canada.
  • Guimond S; University of Ottawa Heart Institute, Ottawa, ON, Canada.
  • deKemp R; Division of Cardiology, University of Ottawa Heart Institute, Ottawa, ON, Canada.
  • Tuominen L; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada.
J Nucl Cardiol ; 28(1): 50-54, 2021 02.
Article en En | MEDLINE | ID: mdl-32909238
ABSTRACT
In contrast to cardiac sympathetic activity which can be assessed with established PET tracers, there are currently no suitable radioligands to measure cardiac parasympathetic (cholinergic) activity. A radioligand able to measure cardiac cholinergic activity would be an invaluable clinical and research tool since cholinergic dysfunction has been associated with a wide array of pathologies (e.g., chronic heart failure, myocardial infarction, arrythmias). [18F]Fluoroethoxybenzovesamicol (FEOBV) is a cholinergic radiotracer that has been extensively validated in the brain. Whether FEOBV PET can be used to assess cholinergic activity in the heart is not known. Hence, this study aimed to evaluate the properties of FEOBV for cardiac PET imaging and cholinergic activity mapping. PET data were collected for 40 minutes after injection of 230 ± 50 MBq of FEOBV in four healthy participants (1 female; Age 37 ± 10; BMI 25 ± 2). Dynamic LV time activity curves were fitted with Logan graphical, 1-tissue compartment, and 2-tissue compartment models, yielding similar distribution volume estimates for each participant. Our initial data show that FEOBV PET has favorable tracer kinetics for quantification of cholinergic activity and is a promising new method for assessing parasympathetic function in the heart.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piperidinas / Tomografía de Emisión de Positrones / Proteínas de Transporte Vesicular de Acetilcolina / Corazón / Miocardio Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Nucl Cardiol Asunto de la revista: CARDIOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Canadá

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piperidinas / Tomografía de Emisión de Positrones / Proteínas de Transporte Vesicular de Acetilcolina / Corazón / Miocardio Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Nucl Cardiol Asunto de la revista: CARDIOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Canadá
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