Supramolecular Catalysis of the oxa-Pictet-Spengler Reaction with an Endohedrally Functionalized Self-Assembled Cage Complex.
Angew Chem Int Ed Engl
; 59(52): 23505-23509, 2020 12 21.
Article
en En
| MEDLINE
| ID: mdl-32914518
ABSTRACT
An endohedrally functionalized self-assembled Fe4 L6 cage complex can catalyze oxa-Pictet-Spengler cyclizations of tryptophols and various aldehyde derivatives, showing strong rate accelerations and size-selectivity. Selective molecular recognition of substrates controls the reactivity, and the cage is capable of binding and activating multiple different species along the multistep reaction pathway. The combination of a functionalized active site, size-selective reactivity, and multistep activation, all from a single host molecule, illustrates the biomimetic nature of the catalysis.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Angew Chem Int Ed Engl
Año:
2020
Tipo del documento:
Article
País de afiliación:
Estados Unidos