Role of GATA3 exon 6 germline mutations in breast cancer progression in Egyptian female patients.
Exp Biol Med (Maywood)
; 246(1): 40-47, 2021 01.
Article
en En
| MEDLINE
| ID: mdl-32938228
ABSTRACT
IMPACT STATEMENT GATA3 mutations are known to play an important role in breast cancer progression. The exact role and mechanisms of these mutations remain controversial as some studies suggest a relation to breast tumor growth, while others suggest a relation to longer survival. GATA3 germline mutations are not well studied in breast cancer. In this study, it was hypothesized that different types of GATA3 mutations could contribute to the breast cancer progression in different ways. GATA3 exon 6, which is important for GATA3 protein functions, was reported to have hotspots, and hence it was selected for study. Intronic GATA3 germline mutations were found to be related to favorable prognosis, while protein coding mutations were found to be related to unfavorable prognosis. Bioinformatics study of large publically available datasets showed that GATA3 mutations lead to dysregulation of pathways related to T-cells activation, inflammation, and breast cancer development.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Mama
/
Exones
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Mutación de Línea Germinal
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Progresión de la Enfermedad
/
Factor de Transcripción GATA3
Tipo de estudio:
Prognostic_studies
Límite:
Female
/
Humans
/
Middle aged
País/Región como asunto:
Africa
Idioma:
En
Revista:
Exp Biol Med (Maywood)
Asunto de la revista:
BIOLOGIA
/
FISIOLOGIA
/
MEDICINA
Año:
2021
Tipo del documento:
Article
País de afiliación:
Egipto