The value of p16 and HPV DNA in non-tonsillar, non-base of tongue oropharyngeal cancer.
Acta Otolaryngol
; 141(1): 89-94, 2021 Jan.
Article
en En
| MEDLINE
| ID: mdl-32940116
ABSTRACT
BACKGROUND:
Oropharyngeal squamous cell carcinoma (OPSCC) is dominated by tonsillar and tongue base carcinomas (TSCC/BOTSCC), but there are carcinomas at other sites, such as uvula/soft palate/pharyngeal wall here defined as other OPSCC. Human papillomavirus (HPV) positive TSCC/BOTSCC have favorable outcome, and the TNM-classification separates OPSCC into HPV mediated (p16INK4a overexpressing, p16+) and HPV unrelated OPSCC (p16INK4a non-overexpressing, p16-) cancer, but the prognostic role of p16+ in other OPSCC is unclear. AIMS/OBJECTIVES:
This study therefore aimed to further investigate the prognostic role of p16+, presence of HPV DNA, or both combined in other OPSCC. MATERIAL ANDMETHODS:
195 other OPSCC, from patients diagnosed 2000-2018 were tested for p16, and/or presence of HPV DNA and the data correlated to outcome.RESULTS:
Neither overall survival, nor disease free survival correlated to presence of p16+ or HPV DNA in other OPSCC. p16+ and HPV DNA presence were correlated (p < .0001), but the sensitivity of p16 as a surrogate marker for presence of HPV DNA was low (49%). CONCLUSIONS ANDSIGNIFICANCE:
The data suggest that p16+ (and p16+/HPV DNA) positive other OPSCC should be analyzed cautiously and possibly separately from the HPV mediated OPSCC staging group.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Lengua
/
Neoplasias Orofaríngeas
/
Regulación Viral de la Expresión Génica
/
Proteínas del Núcleo Viral
/
Infecciones por Papillomavirus
/
Papillomavirus Humano 16
/
Carcinoma de Células Escamosas de Cabeza y Cuello
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
Límite:
Aged
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Acta Otolaryngol
Año:
2021
Tipo del documento:
Article
País de afiliación:
Suecia