Dysfunctional coupling of the parahippocampal cortex and inferior frontal gyrus during memory suppression in posttraumatic stress disorder.
Eur Neuropsychopharmacol
; 41: 146-151, 2020 12.
Article
en En
| MEDLINE
| ID: mdl-32967787
ABSTRACT
The current study aimed to identify alterations in brain activation and connectivity related to memory suppression in posttraumatic stress disorder (PTSD) using the Think/No-Think paradigm during functional magnetic resonance imaging (fMRI). Reduced activation in the parahippocampal cortex during No-Think vs. Baseline trials was found in participants with PTSD compared to controls with no history of trauma (pFWE<0.05). Trauma-related intrusive memories (r = 0.562, p = 0.046) and avoidance behaviors (r = 0.636, p = 0.020) were positively correlated with parahippocampal cortex activation during memory suppression in the PTSD group. Psychophysiological interactions (PPI) analysis identified increased functional connectivity between the inferior frontal gyrus and the parahippocampus during memory suppression in the PTSD group compared to trauma-free controls (pFWE<0.05). Our findings support a network-based phenotype for altered memory suppression in individuals with PTSD rooted in dysfunctional parahippocampal-prefrontal coupling. These data validate neural models of PTSD and offer a novel neural circuit for brain-based interventions targeting trauma-related memory.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Trastornos por Estrés Postraumático
/
Corteza Cerebral
/
Giro Parahipocampal
/
Memoria
Tipo de estudio:
Prognostic_studies
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Eur Neuropsychopharmacol
Asunto de la revista:
PSICOFARMACOLOGIA
Año:
2020
Tipo del documento:
Article
País de afiliación:
Australia