Andrographolide suppresses NLRP3 inflammasome activation in microglia through induction of parkin-mediated mitophagy in in-vitro and in-vivo models of Parkinson disease.

Ahmed, Sahabuddin; Kwatra, Mohit; Ranjan Panda, Samir; Murty, U S N; Naidu, V G M

Ahmed, Sahabuddin; Kwatra, Mohit; Ranjan Panda, Samir; Murty, U S N; Naidu, V G M.

Afiliación

Ahmed S; Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER)-Guwahati, Assam 781101, India.
Kwatra M; Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER)-Guwahati, Assam 781101, India.
Ranjan Panda S; Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER)-Guwahati, Assam 781101, India.
Murty USN; Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER)-Guwahati, Assam 781101, India.
Naidu VGM; Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER)-Guwahati, Assam 781101, India. Electronic address: vgmnaidu@gmail.com.

Brain Behav Immun ; 91: 142-158, 2021 01.

Article en En | MEDLINE | ID: mdl-32971182

Asunto(s)

Microglía; Enfermedad de Parkinson; Animales; Diterpenos; Inflamasomas; Ratones; Ratones Endogámicos C57BL; Mitofagia; Proteína con Dominio Pirina 3 de la Familia NLR; Ubiquitina-Proteína Ligasas

Palabras clave

Andrographolide; Mitochondrial dysfunction; Mitophagy; NLRP3 inflammasome

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Microglía Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Brain Behav Immun Asunto de la revista: ALERGIA E IMUNOLOGIA / CEREBRO / PSICOFISIOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: India

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