Taenia solium proteins: a beautiful kaleidoscope of pro and anti-inflammatory antigens.
Expert Rev Proteomics
; 17(7-8): 609-622, 2020.
Article
en En
| MEDLINE
| ID: mdl-32985289
ABSTRACT
Background:
Neurocysticercosis (NCC) is an acquired infection of central nervous system associated with epileptic seizures. The parasite 'Taenia solium' causes this disease and has a complex life cycle and molts into various stages that influence the host-parasite interaction. The disease has a long asymptomatic phase with viable cyst and degeneration of cyst and leaking cyst fluid has been associated with symptomatic phase. The parasite proteome holds the answers and clues to this complex clinical presentation and hence unraveling of proteome of parasite antigens is needed for better understanding of host-parasite interactions.Objective:
To understand the proteome make-up of T. solium cyst vesicular fluid (VF) and excretory secretory proteins (ESPs).Methodology:
The VF and ESPs for the study were prepared from cyst harvested from naturally infected swine. The samples were prepared for nano LC-MS by in-tube digestion of proteins. The spectra obtained were annotated and enrichment analysis was performed and in silico analysis was done.Results:
T. solium VF and ESPs have 206 and 247 proteins of varied make-up including pro-inflammatory and anti-inflammatory nature.Conclusions:
Due to varied make-up of VF and ESPs it can generate complex humoral and cellular immune response.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
3_ND
Problema de salud:
3_helminthiasis
/
3_neglected_diseases
/
3_zoonosis
Asunto principal:
Neurocisticercosis
/
Proteoma
/
Taenia solium
/
Interacciones Huésped-Parásitos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Expert Rev Proteomics
Asunto de la revista:
BIOQUIMICA
Año:
2020
Tipo del documento:
Article
País de afiliación:
India