Fatty acid profile and antioxidant status in Venus verrucosa gills as λ-cyhalothrin toxic effects.
Toxicol Ind Health
; 36(11): 898-907, 2020 Nov.
Article
en En
| MEDLINE
| ID: mdl-32996380
ABSTRACT
The aim of this study was to analyze the biochemical alterations in the gills of Venus verrucosa under exposure for 6 days to three doses of lambda-cyhalothrin (λ-cyh) (100, 250, and 500 µg L-1). Malondialdehyde, lipid hydroperoxide, and hydrogen peroxide levels in the gills of treated groups increased. λ-Cyh exposure significantly increased the protein carbonyl and reduced glutathione levels in the gills of all treated groups. Moreover, the activities of superoxide dismutase and glutathione peroxidase were increased. In our study, the polyunsaturated fatty acid (FA), omega-6, eicosapentaenoic acid (C205n-3), and docosahexaenoic acid (C226n-3) were increased in the treated groups. A significant decrease in the saturated FAs, omega-3, and arachidonic acid (C204n-6) levels was observed. The content of monounsaturated FA was changed in the groups treated with 100 and 250 µg L-1 of λ-cyh. As a corollary, desaturase and elongase activities were significantly increased. Our study provides evidence of the underlying toxic mechanism of λ-cyh and its capacity to create oxidative stress and revealed that FA profiling is a new approach for elucidating the λ-cyh toxicity.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Plaguicidas
/
Piretrinas
/
Metabolismo de los Lípidos
/
Ácidos Grasos
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Branquias
/
Nitrilos
/
Antioxidantes
Límite:
Animals
Idioma:
En
Revista:
Toxicol Ind Health
Asunto de la revista:
MEDICINA OCUPACIONAL
/
TOXICOLOGIA
Año:
2020
Tipo del documento:
Article
País de afiliación:
Túnez