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Carbonic Anhydrase IX in Renal Cell Carcinoma, Implications for Disease Management.
Courcier, Jean; de la Taille, Alexandre; Nourieh, Maya; Leguerney, Ingrid; Lassau, Nathalie; Ingels, Alexandre.
Afiliación
  • Courcier J; Biomaps, UMR1281, INSERM, Centre National de la Recherche Scientifique (CNRS), Commissariat à l'Energie Atomique (CEA), Université Paris Saclay, 94800 Villejuif, France.
  • de la Taille A; Department of Urology, Henri Mondor Hospital, Université Paris Est Créteil (UPEC), 94000 Créteil, France.
  • Nourieh M; Department of Urology, Henri Mondor Hospital, Université Paris Est Créteil (UPEC), 94000 Créteil, France.
  • Leguerney I; Department of Pathology, Henri Mondor Hospital, UPEC, 94000 Créteil, France.
  • Lassau N; Biomaps, UMR1281, INSERM, Centre National de la Recherche Scientifique (CNRS), Commissariat à l'Energie Atomique (CEA), Université Paris Saclay, 94800 Villejuif, France.
  • Ingels A; Biomaps, UMR1281, INSERM, Centre National de la Recherche Scientifique (CNRS), Commissariat à l'Energie Atomique (CEA), Université Paris Saclay, 94800 Villejuif, France.
Int J Mol Sci ; 21(19)2020 Sep 28.
Article en En | MEDLINE | ID: mdl-32998233
ABSTRACT
Carbonic Anhydrase IX (CAIX) is a well-described enzyme in renal cell carcinoma, with its expression being regulated by the hypoxia-inducible factor 1 alpha, it is known for interfering with hypoxia processes. Renal carcinoma encompasses a broad spectrum of histological entities and is also described as a heterogeneous malignant tumor. Recently, various combinations of checkpoint inhibitors and targeted therapies have been validated to manage this disease. Reliable markers to confirm the diagnosis, estimate the prognosis, predict or monitor the treatment response are required. Molecular imaging developments allow a comprehensive analysis of the tumor, overcoming the spatial heterogeneity issue. CAIX, being highly expressed at the tumor cell surfaces of clear cell renal carcinoma, also represents a potential treatment target. In this manuscript we reviewed the current knowledge from the literature on the pathophysiological interactions between renal cell carcinoma and CAIX, the role of CAIX as a marker for diagnosis, prognosis, treatment monitoring and molecular imaging, and the potential target for therapeutic strategies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Células Renales / Regulación Neoplásica de la Expresión Génica / Terapia Molecular Dirigida / Anhidrasa Carbónica IX / Neoplasias Renales / Hipoxia / Antígenos de Neoplasias Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Int J Mol Sci Año: 2020 Tipo del documento: Article País de afiliación: Francia

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Células Renales / Regulación Neoplásica de la Expresión Génica / Terapia Molecular Dirigida / Anhidrasa Carbónica IX / Neoplasias Renales / Hipoxia / Antígenos de Neoplasias Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Int J Mol Sci Año: 2020 Tipo del documento: Article País de afiliación: Francia
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