Evaluation of photostability and phototoxicity of esterified derivatives of ubiquinol-10 and their application as prodrugs of reduced coenzyme Q<sub>10</sub> for topical administration.

Setoguchi, Shuichi; Nagata-Akaho, Nami; Goto, Shotaro; Yamakawa, Hirofumi; Watase, Daisuke; Terada, Kazuki; Koga, Mitsuhisa; Matsunaga, Kazuhisa; Karube, Yoshiharu; Takata, Jiro

Evaluation of photostability and phototoxicity of esterified derivatives of ubiquinol-10 and their application as prodrugs of reduced coenzyme Q₁₀ for topical administration.

Setoguchi, Shuichi; Nagata-Akaho, Nami; Goto, Shotaro; Yamakawa, Hirofumi; Watase, Daisuke; Terada, Kazuki; Koga, Mitsuhisa; Matsunaga, Kazuhisa; Karube, Yoshiharu; Takata, Jiro.

Afiliación

Setoguchi S; Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan.
Nagata-Akaho N; Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan.
Goto S; Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan.
Yamakawa H; Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan.
Watase D; Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan.
Terada K; Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan.
Koga M; Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan.
Matsunaga K; Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan.
Karube Y; Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan.
Takata J; Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan.

Biofactors ; 46(6): 983-994, 2020 Nov.

Article en En | MEDLINE | ID: mdl-33025665

Asunto(s)

Antioxidantes/metabolismo; Luz/efectos adversos; Profármacos/metabolismo; Ubiquinona/análogos & derivados; Administración Tópica; Antioxidantes/administración & dosificación; Células Cultivadas; Humanos; Queratinocitos/efectos de los fármacos; Profármacos/administración & dosificación; Ubiquinona/administración & dosificación; Ubiquinona/metabolismo

Palabras clave

coenzyme Q; drug delivery; keratinocyte; photostability; phototoxicity; prodrug; skin; ubiquinol

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Profármacos / Ubiquinona / Luz / Antioxidantes Límite: Humans Idioma: En Revista: Biofactors Asunto de la revista: BIOQUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Japón

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