Targeting RNA structures in diseases with small molecules.
Essays Biochem
; 64(6): 955-966, 2020 12 07.
Article
en En
| MEDLINE
| ID: mdl-33078198
ABSTRACT
RNA is crucial for gene expression and regulation. Recent advances in understanding of RNA biochemistry, structure and molecular biology have revealed the importance of RNA structure in cellular processes and diseases. Various approaches to discovering drug-like small molecules that target RNA structure have been developed. This review provides a brief introduction to RNA structural biology and how RNA structures function as disease regulators. We summarize approaches to targeting RNA with small molecules and highlight their advantages, shortcomings and therapeutic potential.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
ARN
/
Bibliotecas de Moléculas Pequeñas
/
Descubrimiento de Drogas
/
Terapia Molecular Dirigida
Límite:
Humans
Idioma:
En
Revista:
Essays Biochem
Año:
2020
Tipo del documento:
Article
País de afiliación:
China