Does chronic systemic injection of the DREADD agonists clozapine-N-oxide or Compound 21 change behavior relevant to locomotion, exploration, anxiety, and depression in male non-DREADD-expressing mice?

Tran, Fionya H; Spears, Stella L; Ahn, Kyung J; Eisch, Amelia J; Yun, Sanghee

Tran, Fionya H; Spears, Stella L; Ahn, Kyung J; Eisch, Amelia J; Yun, Sanghee.

Afiliación

Tran FH; Department of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia (CHOP) Research Institute, Philadelphia, PA, 19104, USA. Electronic address: tranfionya@gmail.com.
Spears SL; Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA, 19104, USA; University Laboratory Animal Resources, University of Pennsylvania, Philadelphia, PA, 19104, USA. Electronic address: stellalspears@gmail.com.
Ahn KJ; Department of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia (CHOP) Research Institute, Philadelphia, PA, 19104, USA. Electronic address: pou3f4@gmail.com.
Eisch AJ; Department of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia (CHOP) Research Institute, Philadelphia, PA, 19104, USA; Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA; Department of Anesthesiology an
Yun S; Department of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia (CHOP) Research Institute, Philadelphia, PA, 19104, USA; Department of Anesthesiology and Critical Care Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. Electronic address: yuns@email.

Neurosci Lett ; 739: 135432, 2020 11 20.

Article en En | MEDLINE | ID: mdl-33080350

Asunto(s)

Conducta Animal/efectos de los fármacos; Clozapina/análogos & derivados; Drogas de Diseño/administración & dosificación; Imidazoles/administración & dosificación; Sulfonamidas/administración & dosificación; Tiofenos/administración & dosificación; Animales; Ansiedad/inducido químicamente; Clozapina/administración & dosificación; Depresión/inducido químicamente; Conducta Exploratoria/efectos de los fármacos; Locomoción/efectos de los fármacos; Masculino; Ratones Endogámicos C57BL; Ratones Transgénicos

Palabras clave

Chemogenetics; Clozapine back-metabolism; Elevated plus maze; Marble burying; Open field; Sucrose splash test

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sulfonamidas / Tiofenos / Conducta Animal / Drogas de Diseño / Clozapina / Imidazoles Límite: Animals Idioma: En Revista: Neurosci Lett Año: 2020 Tipo del documento: Article

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