Two new bioactive polyphenols from the soft coral-derived fungus Talaromyces sp. SCSIO 041201.
Nat Prod Res
; 35(24): 5778-5785, 2021 Dec.
Article
en En
| MEDLINE
| ID: mdl-33107331
ABSTRACT
Two new polyphenols, talaversatilis A (1) and B (2), together with fifteen known compounds (3-17) were isolated from the extract of the culture broth of a soft coral-derived fungus Talaromyces sp. SCSIO 041201. The structures of these compounds were elucidated by the extensive analyses of spectroscopic data and by comparison with the reported literature. Antifouling and antibacterial activities of all purified compounds were tested and evaluated. Compounds 5 and 6 showed antifouling activity towards Bugula neritina larva, with LC50 values of 3.86 µg/mL and 3.05 µg/mL, respectively. Compounds 7, 8, 10 and 13 exhibited significant antibacterial activities against E. coli, MRSA, S. aureus and E. faecalis, with MIC values ranging from 0.45 to 15.6 µg/mL.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
3_ND
Problema de salud:
3_neglected_diseases
/
3_zoonosis
Asunto principal:
Antozoos
/
Talaromyces
Límite:
Animals
Idioma:
En
Revista:
Nat Prod Res
Año:
2021
Tipo del documento:
Article