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Combating acquired resistance to MAPK inhibitors in melanoma by targeting Abl1/2-mediated reactivation of MEK/ERK/MYC signaling.
Tripathi, Rakshamani; Liu, Zulong; Jain, Aditi; Lyon, Anastasia; Meeks, Christina; Richards, Dana; Liu, Jinpeng; He, Daheng; Wang, Chi; Nespi, Marika; Rymar, Andrey; Wang, Peng; Wilson, Melissa; Plattner, Rina.
Afiliación
  • Tripathi R; Department of Pharmacology and Nutritional Sciences, University of Kentucky College of Medicine, Lexington, KY, 40536, USA.
  • Liu Z; Department of Pharmacology and Nutritional Sciences, University of Kentucky College of Medicine, Lexington, KY, 40536, USA.
  • Jain A; Department of Pharmacology and Nutritional Sciences, University of Kentucky College of Medicine, Lexington, KY, 40536, USA.
  • Lyon A; The Jefferson Pancreas, Biliary and Related Cancer Center, Department of Surgery, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA.
  • Meeks C; Department of Pharmacology and Nutritional Sciences, University of Kentucky College of Medicine, Lexington, KY, 40536, USA.
  • Richards D; Department of Pharmacology and Nutritional Sciences, University of Kentucky College of Medicine, Lexington, KY, 40536, USA.
  • Liu J; Department of Pathology, University of Kentucky College of Medicine, Lexington, KY, 40536, USA.
  • He D; Biostatistics and Bioinformatics Shared Resource Facility, Markey Cancer Center, University of Kentucky College of Medicine, Lexington, KY, 40536, USA.
  • Wang C; Biostatistics and Bioinformatics Shared Resource Facility, Markey Cancer Center, University of Kentucky College of Medicine, Lexington, KY, 40536, USA.
  • Nespi M; Biostatistics and Bioinformatics Shared Resource Facility, Markey Cancer Center, University of Kentucky College of Medicine, Lexington, KY, 40536, USA.
  • Rymar A; Plexxikon Inc., Berkeley, CA, 94710, USA.
  • Wang P; Plexxikon Inc., Berkeley, CA, 94710, USA.
  • Wilson M; Department of Internal Medicine, University of Kentucky, College of Medicine, Lexington, KY, USA.
  • Plattner R; Department of Medical Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA.
Nat Commun ; 11(1): 5463, 2020 10 29.
Article en En | MEDLINE | ID: mdl-33122628
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirimidinas / Resistencia a Antineoplásicos / Inhibidores de Proteínas Quinasas / Melanoma Límite: Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirimidinas / Resistencia a Antineoplásicos / Inhibidores de Proteínas Quinasas / Melanoma Límite: Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos