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Association of HERV-K and LINE-1 hypomethylation with reduced disease-free survival in melanoma patients.
Cardelli, Maurizio; Doorn, Remco van; Larcher, Lares; Donato, Michela Di; Piacenza, Francesco; Pierpaoli, Elisa; Giacconi, Robertina; Malavolta, Marco; Rachakonda, Sivaramakrishna; Gruis, Nelleke A; Molven, Anders; Andresen, Per Arne; Pjanova, Dace; van den Oord, Joost J; Provinciali, Mauro; Nagore, Eduardo; Kumar, Rajiv.
Afiliación
  • Cardelli M; Advanced Technology Center for Aging Research, Scientific Technological Area, IRCCS INRCA, 60121 Ancona, Italy.
  • Doorn RV; Department of Dermatology, Leiden University Medical Center, 2300RC Leiden, The Netherlands.
  • Larcher L; Advanced Technology Center for Aging Research, Scientific Technological Area, IRCCS INRCA, 60121 Ancona, Italy.
  • Donato MD; Advanced Technology Center for Aging Research, Scientific Technological Area, IRCCS INRCA, 60121 Ancona, Italy.
  • Piacenza F; Advanced Technology Center for Aging Research, Scientific Technological Area, IRCCS INRCA, 60121 Ancona, Italy.
  • Pierpaoli E; Advanced Technology Center for Aging Research, Scientific Technological Area, IRCCS INRCA, 60121 Ancona, Italy.
  • Giacconi R; Advanced Technology Center for Aging Research, Scientific Technological Area, IRCCS INRCA, 60121 Ancona, Italy.
  • Malavolta M; Advanced Technology Center for Aging Research, Scientific Technological Area, IRCCS INRCA, 60121 Ancona, Italy.
  • Rachakonda S; Division of Molecular Genetic Epidemiology, German Cancer Research Center, 69120 Heidelberg, Germany.
  • Gruis NA; Division of Functional Genome Analysis, German Cancer Research Center, 69120 Heidelberg, Germany.
  • Molven A; Department of Dermatology, Leiden University Medical Center, 2300RC Leiden, The Netherlands.
  • Andresen PA; Gade Laboratory for Pathology, Department of Clinical Medicine, University of Bergen, N-5020 Bergen, Norway.
  • Pjanova D; Department of Pathology, Haukeland University Hospital, N-5021 Bergen, Norway.
  • van den Oord JJ; Department of Pathology, Oslo University Hospital, Rikshospitalet, 0424 Oslo, Norway.
  • Provinciali M; Latvian Biomedical Research & Study Centre, LV-1067 Riga, Latvia.
  • Nagore E; Department of Pathology, University Hospitals Leuven, Belgium.
  • Kumar R; Advanced Technology Center for Aging Research, Scientific Technological Area, IRCCS INRCA, 60121 Ancona, Italy.
Epigenomics ; 12(19): 1689-1706, 2020 10.
Article en En | MEDLINE | ID: mdl-33125285
Aim: To evaluate CpG methylation of long interspersed nuclear elements 1 (LINE-1) and human endogenous retrovirus K (HERV-K) retroelements as potential prognostic biomarkers in cutaneous melanoma. Materials & methods: Methylation of HERV-K and LINE-1 retroelements was assessed in resected melanoma tissues from 82 patients ranging in age from 14 to 88 years. In addition, nevi from eight patients were included for comparison with nonmalignant melanocytic lesions. Results: Methylation levels were lower in melanomas than in nevi. HERV-K and LINE-1 methylation were decreased in melanoma patients with clinical parameters associated with adverse prognosis, while they were independent of age and gender. Hypomethylation of HERV-K (but not LINE-1) was an independent predictor of reduced disease-free survival. Conclusion: HERV-K hypomethylation can be a potential independent biomarker of melanoma recurrence.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Retroelementos / Metilación de ADN / Elementos de Nucleótido Esparcido Largo / Melanoma Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Epigenomics Año: 2020 Tipo del documento: Article País de afiliación: Italia

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Retroelementos / Metilación de ADN / Elementos de Nucleótido Esparcido Largo / Melanoma Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Epigenomics Año: 2020 Tipo del documento: Article País de afiliación: Italia
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