Characterization and preclinical evaluation of a protease activated receptor 2 (PAR2) monoclonal antibody as a preventive therapy for migraine.

Kopruszinski, Caroline M; Thornton, Peter; Arnold, Joanne; Newton, Philip; Lowne, David; Navratilova, Edita; Swiokla, Juliana; Dodick, David W; Dobson, Claire; Gurrell, Ian; Chessell, Iain Patrick; Porreca, Frank

Kopruszinski, Caroline M; Thornton, Peter; Arnold, Joanne; Newton, Philip; Lowne, David; Navratilova, Edita; Swiokla, Juliana; Dodick, David W; Dobson, Claire; Gurrell, Ian; Chessell, Iain Patrick; Porreca, Frank.

Afiliación

Kopruszinski CM; Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, USA.
Thornton P; Neuroscience, R&D BioPharmaceuticals, AstraZeneca, Cambridge, UK.
Arnold J; ADPE, R&D BioPharmaceuticals, AstraZeneca, Cambridge, UK.
Newton P; ADPE, R&D BioPharmaceuticals, AstraZeneca, Cambridge, UK.
Lowne D; ADPE, R&D BioPharmaceuticals, AstraZeneca, Cambridge, UK.
Navratilova E; Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, USA.
Swiokla J; Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, USA.
Dodick DW; Department of Neurology, Mayo Clinic, Phoenix, AZ, USA.
Dobson C; ADPE, R&D BioPharmaceuticals, AstraZeneca, Cambridge, UK.
Gurrell I; Neuroscience, R&D BioPharmaceuticals, AstraZeneca, Cambridge, UK.
Chessell IP; Neuroscience, R&D BioPharmaceuticals, AstraZeneca, Cambridge, UK.
Porreca F; Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, USA.

Cephalalgia ; 40(14): 1535-1550, 2020 12.

Article en En | MEDLINE | ID: mdl-33131305

Asunto(s)

Péptido Relacionado con Gen de Calcitonina; Trastornos Migrañosos; Animales; Anticuerpos Monoclonales; Femenino; Hiperalgesia/prevención & control; Ratones; Ratones Endogámicos C57BL; Trastornos Migrañosos/tratamiento farmacológico; Trastornos Migrañosos/prevención & control; Dolor; Péptido Hidrolasas; Ratas; Receptor PAR-1; Receptor PAR-2

Palabras clave

CGRP; Migraine; PAR2; monoclonal antibody; stress priming; umbellulone

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 1_ASSA2030 Problema de salud: 1_doencas_nao_transmissiveis Asunto principal: Péptido Relacionado con Gen de Calcitonina / Trastornos Migrañosos Límite: Animals Idioma: En Revista: Cephalalgia Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos

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