Comparative effectiveness of nivolumab versus standard of care for third-line patients with small-cell lung cancer.
J Comp Eff Res
; 9(18): 1275-1284, 2020 12.
Article
en En
| MEDLINE
| ID: mdl-33140652
ABSTRACT
Aim:
To estimate the comparative effectiveness of nivolumab versus standard of care (SOC) in terms of overall survival (OS) for small-cell lung cancer patients treated with two prior lines of chemotherapy, in other words, third line in the USA. Materials &methods:
Data were from CheckMate 032, a single-arm trial of nivolumab, and real-world electronic patient records. Comparisons of OS were conducted using three different methods to adjust for differences (regression, weighting and doubly robust) between the populations.Results:
Nivolumab was associated with longer survival compared with SOC (hazard ratio for OS 0.58-0.70) across all methods for adjustment.Conclusion:
Nivolumab was more efficacious in terms of OS as third-line treatment for small-cell lung cancer compared with current SOC in the USA.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Carcinoma de Pulmón de Células no Pequeñas
/
Nivel de Atención
/
Nivolumab
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Neoplasias Pulmonares
Límite:
Humans
Idioma:
En
Revista:
J Comp Eff Res
Año:
2020
Tipo del documento:
Article
País de afiliación:
Canadá