Altered metabolic profiles and biomarkers associated with astragaloside IV-mediated protection against cisplatin-induced acute kidney injury in rats: An HPLC-TOF/MS-based untargeted metabolomics study.

Song, Yanqing; Hu, Tingting; Gao, Huan; Zhai, Jinghui; Gong, Jiawei; Zhang, Yueming; Tao, Lina; Sun, Jingmeng; Li, Zhiyuan; Qu, Xiaoyu

Song, Yanqing; Hu, Tingting; Gao, Huan; Zhai, Jinghui; Gong, Jiawei; Zhang, Yueming; Tao, Lina; Sun, Jingmeng; Li, Zhiyuan; Qu, Xiaoyu.

Afiliación

Song Y; Department of Pharmacy, The First Hospital of Jilin University, Changchun 130021, China.
Hu T; Department of Technical Center, Changchun Customs District, Changchun 130062, China.
Gao H; Department of Pharmacy, The First Hospital of Jilin University, Changchun 130021, China.
Zhai J; Department of Pharmacy, The First Hospital of Jilin University, Changchun 130021, China.
Gong J; Department of Pharmacy, The First Hospital of Jilin University, Changchun 130021, China.
Zhang Y; Department of Pharmacy, The First Hospital of Jilin University, Changchun 130021, China.
Tao L; Department of Pharmacy, The First Hospital of Jilin University, Changchun 130021, China.
Sun J; Department of Pharmacy, The First Hospital of Jilin University, Changchun 130021, China.
Li Z; AB Sciex Analytical Instrument Trading Co., Ltd, Beijing 100015, China.
Qu X; Department of Pharmacy, The First Hospital of Jilin University, Changchun 130021, China. Electronic address: quxiaoyu@jlu.edu.cn.

Biochem Pharmacol ; 183: 114299, 2021 01.

Article en En | MEDLINE | ID: mdl-33148504

Asunto(s)

Lesión Renal Aguda/inducido químicamente; Lesión Renal Aguda/metabolismo; Cisplatino/toxicidad; Metaboloma/fisiología; Metabolómica/métodos; Saponinas/uso terapéutico; Triterpenos/uso terapéutico; Animales; Antineoplásicos/toxicidad; Biomarcadores/metabolismo; Cromatografía Líquida de Alta Presión/métodos; Masculino; Espectrometría de Masas/métodos; Metaboloma/efectos de los fármacos; Ratas; Ratas Sprague-Dawley

Palabras clave

Acute kidney injury; Astragaloside IV; Biomarkers; Cisplatin; Metabolomics

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Saponinas / Triterpenos / Cisplatino / Metaboloma / Metabolómica / Lesión Renal Aguda Tipo de estudio: Risk_factors_studies Límite: Animals Idioma: En Revista: Biochem Pharmacol Año: 2021 Tipo del documento: Article País de afiliación: China

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