Revisiting the role of factor H in age-related macular degeneration: Insights from complement-mediated renal disease and rare genetic variants.

Tzoumas, Nikolaos; Hallam, Dean; Harris, Claire L; Lako, Majlinda; Kavanagh, David; Steel, David H W

Tzoumas, Nikolaos; Hallam, Dean; Harris, Claire L; Lako, Majlinda; Kavanagh, David; Steel, David H W.

Afiliación

Tzoumas N; Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom. Electronic address: nik.tzoumas@ncl.ac.uk.
Hallam D; Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.
Harris CL; Complement Therapeutics Research Group, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom; National Renal Complement Therapeutics Centre, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom.
Lako M; Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.
Kavanagh D; Complement Therapeutics Research Group, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom; National Renal Complement Therapeutics Centre, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom.
Steel DHW; Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom; Sunderland Eye Infirmary, Sunderland, United Kingdom.

Surv Ophthalmol ; 66(2): 378-401, 2021.

Article en En | MEDLINE | ID: mdl-33157112

Asunto(s)

Factor H de Complemento; Degeneración Macular; Factor H de Complemento/genética; Factor H de Complemento/metabolismo; Proteínas del Sistema Complemento/genética; Humanos; Degeneración Macular/genética; Fenotipo; Proteómica

Palabras clave

C3 glomerulopathy; age-related macular degeneration; alternative pathway; atypical hemolytic uremic syndrome; complement factor H; complement system; complement therapeutics; genetic variants; pharmacogenomics; subretinal inflammation

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factor H de Complemento / Degeneración Macular Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Surv Ophthalmol Año: 2021 Tipo del documento: Article

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