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The Biological Function of Extracellular Vesicles during Fertilization, Early Embryo-Maternal Crosstalk and Their Involvement in Reproduction: Review and Overview.
Capra, Emanuele; Lange-Consiglio, Anna.
Afiliación
  • Capra E; Istituto di Biologia e Biotecnologia Agraria, Consiglio Nazionale delle Ricerche IBBA CNR, 26900 Lodi, Italy.
  • Lange-Consiglio A; Dipartimento di Medicina Veterinaria, Università degli Studi di Milano, 26900 Lodi, Italy.
Biomolecules ; 10(11)2020 11 04.
Article en En | MEDLINE | ID: mdl-33158009
ABSTRACT
Secretory extracellular vesicles (EVs) are membrane-enclosed microparticles that mediate cell to cell communication in proximity to, or distant from, the cell of origin. Cells release a heterogeneous spectrum of EVs depending on their physiologic and metabolic state. Extracellular vesicles are generally classified as either exosomes or microvesicles depending on their size and biogenesis. Extracellular vesicles mediate temporal and spatial interaction during many events in sexual reproduction and supporting embryo-maternal dialogue. Although many omic technologies provide detailed understanding of the molecular cargo of EVs, the difficulty in obtaining populations of homogeneous EVs makes difficult to interpret the molecular profile of the molecules derived from a miscellaneous EV population. Notwithstanding, molecular characterization of EVs isolated in physiological and pathological conditions may increase our understanding of reproductive and obstetric diseases and assist the search for potential non-invasive biomarkers. Moreover, a more precise vision of the cocktail of biomolecules inside the EVs mediating communication between the embryo and mother could provide new insights to optimize the therapeutic action and safety of EV use.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Reproducción / Embrión de Mamíferos / Vesículas Extracelulares / Madres Límite: Animals / Humans Idioma: En Revista: Biomolecules Año: 2020 Tipo del documento: Article País de afiliación: Italia

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Reproducción / Embrión de Mamíferos / Vesículas Extracelulares / Madres Límite: Animals / Humans Idioma: En Revista: Biomolecules Año: 2020 Tipo del documento: Article País de afiliación: Italia
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