Hepatitis B vaccine coverage and risk factors for lack of vaccination in subjects with HBsAg negative liver cirrhosis in Italy: still, much work should be done.
Dig Liver Dis
; 53(10): 1315-1319, 2021 Oct.
Article
en En
| MEDLINE
| ID: mdl-33162352
ABSTRACT
BACKGROUND:
in Italy, Hepatitis-B-vaccine is advised and provided free-of-charge for subjects with chronic liver disease (CLD), including liver cirrhosis.AIMS:
to evaluate HB-vaccine-coverage and variables associated with lack of vaccination in cirrhotic patients with particular attention to cirrhosis' etiology.METHODS:
cirrhotic patients of any etiology (excluding HBsAg+) referring to 8 tertiary-centers were prospectively enrolled for a-six-months-period in 2019. Subjects were asked if they received HB-vaccine previously. Multiple-logistic-regression-analysis was performed to identify independent predictors of lack of vaccination.RESULTS:
731 cases were recruited. Overall-vaccine-coverage was 16.3% (23.7% in those younger than 65y, 10.0% in those older than 64y; p<0.001). Lack of information was the most frequent reason (78.5% of cases) reported by the 608 unvaccinated subjects, without statistical difference by area-of-birth (77.3% in Italians, 80.0% in people-born-abroad). Age>64 y (OR 4.27; CI 95% 2.52-7.24), educational level<9 years (OR 3.52; CI 95% 2.10-5.90), residence in South/Sardinia (OR 2.52; CI 95%1.45-4.39), birth-abroad (OR 5.09; CI 95% 1.07-24-.17), and Child grade B/C(OR 2.68; CI 95% 1.35-5.33) all resulted independent predictors of likelihood of lack of vaccination.CONCLUSIONS:
Vaccination-rate in cirrhotic patients results very low. Vaccine-coverage implementation in these subjects, is warranted. Vaccine should be provided in early CLD, when immunization is most effective.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
1_ASSA2030
/
2_ODS3
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4_TD
Problema de salud:
1_doencas_transmissiveis
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2_enfermedades_transmissibles
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4_hepatitis
Asunto principal:
Vacunas contra Hepatitis B
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Cobertura de Vacunación
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Cirrosis Hepática
Tipo de estudio:
Clinical_trials
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Etiology_studies
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Observational_studies
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Prevalence_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Aged
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Female
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Humans
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Male
/
Middle aged
País/Región como asunto:
Europa
Idioma:
En
Revista:
Dig Liver Dis
Asunto de la revista:
GASTROENTEROLOGIA
Año:
2021
Tipo del documento:
Article
País de afiliación:
Italia