CACNA1C methylation: association with cortisol, perceived stress, rs1006737 and childhood trauma in males.
Epigenomics
; 12(19): 1739-1749, 2020 10.
Article
en En
| MEDLINE
| ID: mdl-33169621
ABSTRACT
Aim:
We investigated morning cortisol, stress, rs1006737 and childhood trauma relationship with CACNA1C methylation. Materials &methods:
Morning cortisol release, childhood trauma and perceived stress were collected and genotyping for rs1006737 conducted in 103 adult males. Genomic DNA extracted from saliva was bisulphite converted and using pyrosequencing methylation determined at 11 CpG sites within intron 3 of CACNA1C.Results:
A significant negative correlation between waking cortisol and overall mean methylation was found and a positive correlation between CpG5 methylation and perceived stress.Conclusion:
CACNA1C methylation levels may be related to cortisol release and stress perception. Future work should evaluate the influence of altered CACNA1C methylation on stress reactivity to investigate this as a potential mechanism for mental health vulnerability.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Estrés Psicológico
/
Hidrocortisona
/
Canales de Calcio Tipo L
/
Experiencias Adversas de la Infancia
Tipo de estudio:
Risk_factors_studies
Límite:
Adult
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Epigenomics
Año:
2020
Tipo del documento:
Article
País de afiliación:
Reino Unido