Walking activity in a large cohort of boys with Duchenne muscular dystrophy.
Muscle Nerve
; 63(2): 192-198, 2021 02.
Article
en En
| MEDLINE
| ID: mdl-33188573
ABSTRACT
INTRODUCTION:
In this study we explored walking activity in a large cohort of boys with Duchenne muscular dystrophy (DMD).METHODS:
Step activity (monitored for 7 days), functional ability, and strength were quantified in ambulatory boys (5-12.9 years of age) with DMD and unaffected boys. Ambulatory status was determined 2 years later.RESULTS:
Two to 5 days of activity monitoring predicted weekly step activity (adjusted R2 = 0.80-0.95). Age comparisons revealed significant declines for step activity with increasing age, and relationships were found between step activity with both function and strength (P < .01). Our regression model predicted 36.5% of the variance in step activity. Those who were still ambulatory after 2 years demonstrated baseline step activity nearly double that of those who were no longer walking 2 years later (P < .01).DISCUSSION:
Step activity for DMD is related to and predictive of functional declines, which may be useful for clinical trials.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ejercicio Físico
/
Caminata
/
Distrofia Muscular de Duchenne
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Child
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Child, preschool
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Humans
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Male
Idioma:
En
Revista:
Muscle Nerve
Año:
2021
Tipo del documento:
Article
País de afiliación:
Estados Unidos