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Synthesis of Guaianolide Analogues with a Tunable α-Methylene-γ-lactam Electrophile and Correlating Bioactivity with Thiol Reactivity.
Jackson, Paul A; Schares, Henry A M; Jones, Katherine F M; Widen, John C; Dempe, Daniel P; Grillet, Francois; Cuellar, Matthew E; Walters, Michael A; Harki, Daniel A; Brummond, Kay M.
Afiliación
  • Jackson PA; Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States.
  • Schares HAM; Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States.
  • Jones KFM; Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States.
  • Widen JC; Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States.
  • Dempe DP; Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States.
  • Grillet F; Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States.
  • Cuellar ME; Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States.
  • Walters MA; Institute for Therapeutics Discovery and Development, University of Minnesota, Minneapolis, Minnesota 55455, United States.
  • Harki DA; Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States.
  • Brummond KM; Institute for Therapeutics Discovery and Development, University of Minnesota, Minneapolis, Minnesota 55455, United States.
J Med Chem ; 63(23): 14951-14978, 2020 12 10.
Article en En | MEDLINE | ID: mdl-33201697
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cisteamina / Sesquiterpenos de Guayano / Lactamas Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cisteamina / Sesquiterpenos de Guayano / Lactamas Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos