Cognitive and behavioral risk factors for low quality of life in survivors of childhood acute lymphoblastic leukemia.
Pediatr Res
; 90(2): 419-426, 2021 08.
Article
en En
| MEDLINE
| ID: mdl-33203967
ABSTRACT
BACKGROUND:
With high survival rates for pediatric acute lymphoblastic leukemia (ALL), long-term quality of life is a prominent consideration in treatment. We concurrently evaluated cognition, behavior, and quality of life in child and adolescent ALL survivors and determined associations between them.METHODS:
The sample included 83 controls (mean age 12.5 years) and 71 ALL survivors (mean age 11.9 years, mean age at diagnosis 3.8 years). Participants completed measures of general intellectual abilities, math achievement, and fine motor skills. Parents and teachers completed a survey assessing child participants' cognitive, behavioral, and emotional function. Parents additionally completed a survey about their child's quality of life.RESULTS:
Survivors had lower scores on measures of working memory, processing speed, timed math, and fine motor skills (effect size 0.5-1, p < 0.001). Parents identified more problems with executive function and learning in survivors than controls (effect size > 0.7, p < 0.001), and indicated a lower quality of life in all categories evaluated (effect size > 0.7, p < 10-4). Reduced quality of life was associated with lower math achievement scores and with inattention and executive function problems.CONCLUSIONS:
ALL survivors experience diffuse cognitive, behavioral, and motor impairments, which are associated with reduced quality of life. These findings underscore the need to address these challenges in ALL survivors. IMPACT Compared with cancer-free peers, parents of childhood acute lymphoblastic leukemia survivors treated with chemotherapy only reported reduced quality of life. Math difficulties and behavioral problems increased the risk for reduced quality of life. Reduced quality of life is associated with mild cognitive and behavioral difficulties, suggesting that even relatively mild impairments have broad implications for ALL survivors. Screening and early intervention targeting cognitive and behavioral function may enhance quality of life for ALL survivors.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Calidad de Vida
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Conducta Infantil
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Desarrollo Infantil
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Conducta del Adolescente
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Cognición
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Desarrollo del Adolescente
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Leucemia-Linfoma Linfoblástico de Células Precursoras
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Supervivientes de Cáncer
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Qualitative_research
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Risk_factors_studies
Aspecto:
Patient_preference
Límite:
Adolescent
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Child
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Child, preschool
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Female
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Humans
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Male
Idioma:
En
Revista:
Pediatr Res
Año:
2021
Tipo del documento:
Article
País de afiliación:
Estados Unidos