Ethanol consumption synergistically increases ultraviolet radiation induced skin damage and immune dysfunction.
J Dermatol Sci
; 101(1): 40-48, 2021 Jan.
Article
en En
| MEDLINE
| ID: mdl-33213984
ABSTRACT
BACKGROUND:
Excessive UV radiation disrupts skin homeostasis by multiple mechanisms that extend beyond the simple erythema associated with sunburns including reduction of antioxidants, increased DNA damage, and impairment of skin immune responses. Recreational UV exposure frequently occurs concurrently with excessive ethanol (EtOH). Epidemiological studies suggest a harmful, dose-dependent impact of EtOH in the setting of high UV exposure, leading to increased severity of sunburns relative to those generated in the absence of EtOH. Furthermore, EtOH consumption and UV radiation have multiple overlapping effects on the skin that could account for the epidemiological association.OBJECTIVE:
To elucidate the relationship between excessive EtOH ingestion and UV exposures on early skin damage and downstream immune dysfunction.METHODS:
We examined the impact of UVB on local skin damage, including inflammation, sunburned cells, apoptotic cells, melanin and antioxidant levels, DNA damage and immune dysfunction in the presence or absence of EtOH ingestion by combining standard mouse models of EtOH consumption and UVB exposure models. To confirm that the observed changes in mouse skin were relevant to human skin, we investigated the effects of EtOH on UV-induced skin damage with human skin explants.RESULTS:
We demonstrated that EtOH consumption and UV exposure act synergistically to increase the severity of local skin damage resulting in impaired melanin responses, reduced antioxidants, greater DNA damage, and immune dysfunction as measured by reduced contact hypersensitivity.CONCLUSIONS:
The results support incorporation of the risks of combined UV exposure and excessive alcohol consumption into public health campaigns.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
1_ASSA2030
Problema de salud:
1_doencas_nao_transmissiveis
Asunto principal:
Piel
/
Neoplasias Cutáneas
/
Quemadura Solar
/
Rayos Ultravioleta
/
Consumo de Bebidas Alcohólicas
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Female
/
Humans
/
Male
/
Newborn
Idioma:
En
Revista:
J Dermatol Sci
Asunto de la revista:
DERMATOLOGIA
Año:
2021
Tipo del documento:
Article