p53 and RB1 regulate Hedgehog responsiveness via autophagy-mediated ciliogenesis.
Mol Cell Oncol
; 7(6): 1805095, 2020 Sep 08.
Article
en En
| MEDLINE
| ID: mdl-33235907
ABSTRACT
Loss of tumor protein p53 (p53) and RB transcriptional corepressor 1 (RB1) in developmental and small cell lung cancer models promotes primary cilia formation and hyper-responsiveness to Hedgehog ligand. This is mediated by impaired transcription of p53 and RB1 target genes involved in autophagic degradation of primary cilia.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Mol Cell Oncol
Año:
2020
Tipo del documento:
Article
País de afiliación:
Australia