Stimulation of epidermal hyperplasia and tumorigenesis by resident p16INK4a-expressing cells.
Mol Cell Oncol
; 7(6): 1819752, 2020 Sep 25.
Article
en En
| MEDLINE
| ID: mdl-33235916
ABSTRACT
p16INK4a (CDKN2A) is a central tumor-suppressor and activator of senescence. We recently found that prolonged expression of p16INK4a in epidermal cells induces hyperplasia and dysplasia through Wnt-mediated stimulation of neighboring keratinocytes. The study suggests a pro-tumorigenic function of p16INK4a in early epidermal lesions, which could potentially be targeted by senolytic therapy.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Mol Cell Oncol
Año:
2020
Tipo del documento:
Article
País de afiliación:
Israel