WNT: an unexpected tumor suppressor in medulloblastoma.

Manoranjan, Branavan; Adile, Ashley A; Venugopal, Chitra; Singh, Sheila K

Manoranjan, Branavan; Adile, Ashley A; Venugopal, Chitra; Singh, Sheila K.

Afiliación

Manoranjan B; Section of Neurosurgery, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada.
Adile AA; Departments of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.
Venugopal C; Surgery, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
Singh SK; Departments of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.

Mol Cell Oncol ; 7(6): 1834903, 2020.

Article en En | MEDLINE | ID: mdl-33241114

ABSTRACT

ABSTRACT

Medulloblastoma (MB) represents the most common malignant pediatric brain tumor and is defined by four molecular subgroups with WNT MB having the most favorable prognosis. Our work provides a rational therapeutic option in which the protective effects of WNT-driven MBs may be augmented in Group 3 and 4 MB.

Palabras clave

Medulloblastoma; WNT; beta-catenin; brain tumor-initiating cell

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Mol Cell Oncol Año: 2020 Tipo del documento: Article País de afiliación: Canadá

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