Ciamexon in the low dose streptozotocin induced diabetes of mice.
Diabetes Res
; 6(3): 113-7, 1987 Nov.
Article
en En
| MEDLINE
| ID: mdl-3325216
ABSTRACT
This article is concerned with suppression of the development of diabetes experimentally induced by multiple injections of subdiabetogenic doses of streptozotocin (4 x 45 mg/kg/d) in mice (CD 1 and C57B16). Streptozotocin injections were followed by hyperglycemia and mononuclear cell infiltration of islets (insulitis). Ciamexon is a new immuno-modulating agent with promising effects in experimental models of autoimmune diseases and practically no toxic side effects. When Ciamexon was given before streptozotocin treatment blood glucose levels in the parenteral glucose tolerance test were suppressed in a dose dependent way. 60 days after streptozotocin application the percentage of islets showing insulitis or even necrosis was reduced in the Ciamexon treated group compared to the streptozotocin only group. In contrast, Cyclosporin A had a detrimental effect on diabetes in this model although blood levels were proved to be in the therapeutic range. From these results we conclude that Ciamexon should be tested for its effect in human type I diabetes.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Aziridinas
/
Azirinas
/
Ciclosporinas
/
Diabetes Mellitus Experimental
Límite:
Animals
Idioma:
En
Revista:
Diabetes Res
Asunto de la revista:
ENDOCRINOLOGIA
Año:
1987
Tipo del documento:
Article