Cyclic peptide engineered from phytocystatin inhibitory hairpin loop as an effective modulator of falcipains and potent antimalarial.

Mishra, Manasi; Singh, Vigyasa; Tellis, Meenakshi B; Joshi, Rakesh S; Pandey, Kailash C; Singh, Shailja

Mishra, Manasi; Singh, Vigyasa; Tellis, Meenakshi B; Joshi, Rakesh S; Pandey, Kailash C; Singh, Shailja.

Afiliación

Mishra M; Department of Life Sciences, School of Natural Sciences, Shiv Nadar University, Uttar Pradesh, India.
Singh V; Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi, India.
Tellis MB; Division of Biochemical Sciences, CSIR-National Chemical Laboratory, Pune, India.
Joshi RS; Division of Biochemical Sciences, CSIR-National Chemical Laboratory, Pune, India.
Pandey KC; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.
Singh S; Parasite-Host Biology Group, ICMR National Institute of Malaria Research, Dwarka, India.

J Biomol Struct Dyn ; 40(8): 3642-3654, 2022 05.

Article en En | MEDLINE | ID: mdl-33292080

Asunto(s)

Antimaláricos; Proteasas de Cisteína; Antagonistas del Ácido Fólico; Malaria Falciparum; Antimaláricos/química; Inhibidores de Cisteína Proteinasa/farmacología; Antagonistas del Ácido Fólico/farmacología; Humanos; Malaria Falciparum/tratamiento farmacológico; Péptidos/farmacología; Péptidos Cíclicos/farmacología; Plasmodium falciparum

Palabras clave

P. falciparum; Phytocystatin; cyclic peptide; falcipain inhibitors; proteinprotein interaction mimics

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 3_ND Problema de salud: 3_malaria / 3_neglected_diseases Asunto principal: Malaria Falciparum / Proteasas de Cisteína / Antagonistas del Ácido Fólico / Antimaláricos Límite: Humans Idioma: En Revista: J Biomol Struct Dyn Año: 2022 Tipo del documento: Article País de afiliación: India

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