Understanding and modulating the MR1 metabolite antigen presentation pathway.
Mol Immunol
; 129: 121-126, 2021 01.
Article
en En
| MEDLINE
| ID: mdl-33293099
ABSTRACT
The MHC class I-related protein, MR1, presents small metabolite antigens to an unusual subset of innate-like T cells. Herein, we highlight recent progress in our understanding of MR1's unique antigen presenting pathway, with features of both MHC class I and class II antigen presentation, as highlighted during the EMBO Workshop CD1-MR1, Beyond MHC-restricted lymphocytes, Oxford, 2019. There is increasing evidence for a role of MR1 restricted T cells in several immune contexts, from cancer to autoimmunity and infections, and therapeutic harnessing of this important biological axis through generation of agonist and antagonist MR1 ligands requires a thorough understanding of the molecular mechanisms of MR1-dependent antigen presentation.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Antígenos de Histocompatibilidad Clase I
/
Presentación de Antígeno
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Células T Invariantes Asociadas a Mucosa
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Mol Immunol
Año:
2021
Tipo del documento:
Article