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Interleukin-18 Is a Prognostic Marker and Plays a Tumor Suppressive Role in Colon Cancer.
Feng, Xiaodong; Zhang, Zhijun; Sun, Peng; Song, Guanghui; Wang, Lu; Sun, Zhenqing; Yuan, Ning; Wang, Qing; Lun, Limin.
Afiliación
  • Feng X; Department of Clinical Laboratory, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao 266000, China.
  • Zhang Z; Department of Clinical Laboratory, Taian City Central Hospital, Taian 271000, China.
  • Sun P; Department of Pathology, Taian City Central Hospital, Taian 271000, China.
  • Song G; Department of Clinical Laboratory, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao 266000, China.
  • Wang L; Department of Education and Training, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao 266000, China.
  • Sun Z; Department of General Surgery, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao 266000, China.
  • Yuan N; Department of Clinical Laboratory, The Seventh Medical Center of PLA General Hospital, Bejing 100010, China.
  • Wang Q; Department of Clinical Laboratory, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao 266000, China.
  • Lun L; Department of Clinical Laboratory, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao 266000, China.
Dis Markers ; 2020: 6439614, 2020.
Article en En | MEDLINE | ID: mdl-33294056
ABSTRACT
Interleukin-18 (IL-18) belongs to the IL-1 family and is an essential proinflammatory and immune regulatory cytokine. The present study was designed to investigate the expression and function of IL-18 in colon cancer. In clinical analyses, mRNA and protein expressions of IL-18 were decreased in tissues of colon cancer patients. This decreased expression of IL-18 was significantly correlated with the tumor size (P = 0.001) and American Joint Committee on Cancer (AJCC) stage (P = 0.013). Patients with IL-18-positive tumors had a better survival rate than patients with IL-18-negative tumors. Moreover, upregulation of IL-18 inhibited colon cancer cell proliferation. Our data suggest that the decreased expression of IL-18 in colon cancer was associated with prognosis and tumor proliferation. IL-18 may be considered a novel tumor suppressor and a potential therapeutic target for colon cancer patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Regulación hacia Abajo / Neoplasias del Colon / Interleucina-18 Tipo de estudio: Prognostic_studies Límite: Female / Humans / Male Idioma: En Revista: Dis Markers Asunto de la revista: BIOQUIMICA Año: 2020 Tipo del documento: Article País de afiliación: China
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Regulación hacia Abajo / Neoplasias del Colon / Interleucina-18 Tipo de estudio: Prognostic_studies Límite: Female / Humans / Male Idioma: En Revista: Dis Markers Asunto de la revista: BIOQUIMICA Año: 2020 Tipo del documento: Article País de afiliación: China