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Hyperbaric Oxygen Therapy Did Not Prevent Delayed Neuropsychiatric Sequelae in a Prospective Observational Study With Propensity Score Matching in 224 Patients With Acute Carbon Monoxide Toxicity.
Han, Sangsoo; Nah, Sangun; Choi, Sungwoo; Lee, Young Hwan; Kim, Gi Woon; Cho, Young Soon.
Afiliación
  • Han S; Department of Emergency Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea.
  • Nah S; Department of Emergency Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea.
  • Choi S; Department of Emergency Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea.
  • Lee YH; Department of Emergency Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea.
  • Kim GW; Department of Emergency Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea.
  • Cho YS; Department of Emergency Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea.
J Emerg Med ; 60(4): 498-505, 2021 Apr.
Article en En | MEDLINE | ID: mdl-33298359
ABSTRACT

BACKGROUND:

It is important to prevent the development of delayed neuropsychiatric sequelae (DNS) in acute carbon monoxide (CO) intoxication, but no effective treatment has been clearly identified. Hyperbaric oxygen (HBO) therapy is one of the treatment options in acute CO poisoning; however, whether it can prevent the development of DNS is controversial.

OBJECTIVES:

The purpose of this study is to compare the effectiveness of normobaric oxygen (NBO) and HBO in preventing DNS.

METHODS:

This prospective observational study was conducted on all patients with CO poisoning admitted to the emergency department of a tertiary hospital from 2016 to 2019. We followed-up patients to determine whether symptoms of DNS occurred at ≤6 months. We matched the propensity score to an equivalent distribution of potential covariates.

RESULTS:

A total of 224 patients with CO poisoning were enrolled in this study. NBO was used for 26 patients and HBO for 198 patients. DNS occurred in 40 patients. There were significant differences between the NBO and HBO groups in terms of carboxyhemoglobin, loss of consciousness, dizziness, chest pain, hospitalization, and length of hospital stay. The incidence of DNS was 19.2% in the HBO group, which was higher than the 7.7% observed in the NBO group, but the difference was not significant (p = 0.18). After propensity score matching, the incidence of DNS did not differ between the NBO and HBO groups (8.3% vs. 10.4%, p > 0.99).

CONCLUSION:

There was no difference in the incidence of DNS between groups receiving HBO and NBO in acute CO intoxication.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Intoxicación por Monóxido de Carbono / Oxigenoterapia Hiperbárica Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: J Emerg Med Asunto de la revista: MEDICINA DE EMERGENCIA Año: 2021 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Intoxicación por Monóxido de Carbono / Oxigenoterapia Hiperbárica Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: J Emerg Med Asunto de la revista: MEDICINA DE EMERGENCIA Año: 2021 Tipo del documento: Article
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