A new electrochemical sensing platform based on HgS/graphene composite deposited on the glassy carbon electrode for selective and sensitive determination of propranolol.
J Pharm Biomed Anal
; 194: 113653, 2021 Feb 05.
Article
en En
| MEDLINE
| ID: mdl-33303269
ABSTRACT
Fabrication of selective, sensitive and reliable sensing platform for detection of propranolol (PRO) is still a great challenge. In this study, a new sensitive and selective electrochemical sensor was fabricated for the electrochemical determination of PRO using HgS/graphene composite. The incorporation of HgS microstructures on graphene sheets was done via a facile one-step method, where the simultaneous reduction of GO and the in-situ generation of HgS happened. Owing to the large surface area, excellent electronic conductivity and more electro-active sites provided by graphene, the HgS/graphene composite exhibited better electrochemical ability through the detection of PRO compared to the bare HgS. The HgS/graphene sensor revealed superb selectivity, good repeatability and superior stability of about 96.0 % of its original response after five weeks. Moreover, the sensor displayed excellent analytical parameters such as linear range of 0.5-50.0 µM with low detection limit of 0.05 µM (S/N = 3) and good sensitivity (0.1851 µA/µM). Furthermore, the constructed sensor was applied for detection of PRO in real and pharmaceutical samples, with good recoveries, ranging from 96.0 to 102.0%. The HgS/graphene composite provided here displayed satisfactory electrochemical features may hold great potential to the improvement of electrochemical sensors and electronic devices.
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Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Grafito
Tipo de estudio:
Diagnostic_studies
Idioma:
En
Revista:
J Pharm Biomed Anal
Año:
2021
Tipo del documento:
Article
País de afiliación:
Irán