A novel danshensu/tetramethypyrazine derivative attenuates oxidative stress-induced autophagy injury via the AMPK-mTOR-Ulk1 signaling pathway in cardiomyocytes.

Xie, Caipeng; Luo, Jingxiong; Hu, Huihui; Wang, Liang; Yu, Pei; Xu, Lipeng; Sun, Yewei; Wang, Yuqiang; Shan, Luchen

Xie, Caipeng; Luo, Jingxiong; Hu, Huihui; Wang, Liang; Yu, Pei; Xu, Lipeng; Sun, Yewei; Wang, Yuqiang; Shan, Luchen.

Afiliación

Xie C; Institute of New Drug Research and Guangzhou Key Laboratory of Innovative Chemical Drug Research in Cardio-cerebrovascular Diseases, Jinan University College of Pharmacy, Guangzhou, Guangdong 510000, P.R. China.
Luo J; Institute of New Drug Research and Guangzhou Key Laboratory of Innovative Chemical Drug Research in Cardio-cerebrovascular Diseases, Jinan University College of Pharmacy, Guangzhou, Guangdong 510000, P.R. China.
Hu H; Institute of New Drug Research and Guangzhou Key Laboratory of Innovative Chemical Drug Research in Cardio-cerebrovascular Diseases, Jinan University College of Pharmacy, Guangzhou, Guangdong 510000, P.R. China.
Wang L; Institute of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, Guangdong 510006, P.R. China.
Yu P; Institute of New Drug Research and Guangzhou Key Laboratory of Innovative Chemical Drug Research in Cardio-cerebrovascular Diseases, Jinan University College of Pharmacy, Guangzhou, Guangdong 510000, P.R. China.
Xu L; Institute of New Drug Research and Guangzhou Key Laboratory of Innovative Chemical Drug Research in Cardio-cerebrovascular Diseases, Jinan University College of Pharmacy, Guangzhou, Guangdong 510000, P.R. China.
Sun Y; Institute of New Drug Research and Guangzhou Key Laboratory of Innovative Chemical Drug Research in Cardio-cerebrovascular Diseases, Jinan University College of Pharmacy, Guangzhou, Guangdong 510000, P.R. China.
Wang Y; Institute of New Drug Research and Guangzhou Key Laboratory of Innovative Chemical Drug Research in Cardio-cerebrovascular Diseases, Jinan University College of Pharmacy, Guangzhou, Guangdong 510000, P.R. China.
Shan L; Institute of New Drug Research and Guangzhou Key Laboratory of Innovative Chemical Drug Research in Cardio-cerebrovascular Diseases, Jinan University College of Pharmacy, Guangzhou, Guangdong 510000, P.R. China.

Exp Ther Med ; 21(2): 118, 2021 Feb.

Article en En | MEDLINE | ID: mdl-33335581

Palabras clave

5'-AMP-activated protein kinase/mTOR/unc-51 like autophagy activating kinase 1 signaling pathway; autophagy; cardioprotection; danshensu/tetramethylpyrazine derivative; oxidative stress

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Exp Ther Med Año: 2021 Tipo del documento: Article