Hepatic stellate cells specific liposomes with the Toll-like receptor 4 shRNA attenuates liver fibrosis.

Zhang, Yuwei; Li, Yang; Mu, Tong; Tong, Nanwei; Cheng, Ping

Zhang, Yuwei; Li, Yang; Mu, Tong; Tong, Nanwei; Cheng, Ping.

Afiliación

Zhang Y; Division of Endocrinology and Metabolism, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, China.
Li Y; Division of Endocrinology and Metabolism, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, China.
Mu T; Division of Endocrinology and Metabolism, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, China.
Tong N; Division of Endocrinology and Metabolism, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, China.
Cheng P; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, China.

J Cell Mol Med ; 25(2): 1299-1313, 2021 01.

Article en En | MEDLINE | ID: mdl-33336563

Asunto(s)

Células Estrelladas Hepáticas/metabolismo; Cirrosis Hepática/terapia; ARN Interferente Pequeño/metabolismo; Receptor Toll-Like 4/metabolismo; Animales; Citocinas/metabolismo; ADN/metabolismo; Progresión de la Enfermedad; Matriz Extracelular/metabolismo; Femenino; Silenciador del Gen; Mediadores de Inflamación/metabolismo; Lipopolisacáridos; Liposomas; Cirrosis Hepática/patología; Ratones Endogámicos C57BL; Mitocondrias/metabolismo; NADPH Oxidasas/metabolismo; FN-kappa B/genética; FN-kappa B/metabolismo; Especies Reactivas de Oxígeno/metabolismo; Distribución Tisular; Transcripción Genética; Vitamina A/metabolismo; Vitamina A/farmacocinética

Palabras clave

RNA interference; Toll-like receptor 4; hepatic stellate cells; liver fibrosis; reactive oxygen species

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ARN Interferente Pequeño / Receptor Toll-Like 4 / Células Estrelladas Hepáticas / Cirrosis Hepática Límite: Animals Idioma: En Revista: J Cell Mol Med Asunto de la revista: BIOLOGIA MOLECULAR Año: 2021 Tipo del documento: Article País de afiliación: China

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