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Distinctive Features of Kawasaki Disease Following SARS-CoV-2 Infection: a Controlled Study in Paris, France.
Toubiana, Julie; Cohen, Jérémie F; Brice, Joséphine; Poirault, Clément; Bajolle, Fanny; Curtis, William; Moulin, Florence; Matczak, Soraya; Leruez, Marianne; Casanova, Jean-Laurent; Chalumeau, Martin; Taylor, Melissa; Allali, Slimane.
Afiliación
  • Toubiana J; Department of General Pediatrics and Pediatric Infectious Diseases, Necker-Enfants Malades University Hospital, Assistance Publique - Hôpitaux de Paris (AP-HP), Necker Hospital for Sick Children, Université de Paris, 75015, Paris, France. julie.toubiana@aphp.fr.
  • Cohen JF; Biodiversity and Epidemiology of Bacterial Pathogens, Institut Pasteur, Paris, France. julie.toubiana@aphp.fr.
  • Brice J; Department of General Pediatrics and Pediatric Infectious Diseases, Necker-Enfants Malades University Hospital, Assistance Publique - Hôpitaux de Paris (AP-HP), Necker Hospital for Sick Children, Université de Paris, 75015, Paris, France.
  • Poirault C; Centre of Research in Epidemiology and Statistics - CRESS, INSERM, Université de Paris, F-75004, Paris, France.
  • Bajolle F; Department of General Pediatrics and Pediatric Infectious Diseases, Necker-Enfants Malades University Hospital, Assistance Publique - Hôpitaux de Paris (AP-HP), Necker Hospital for Sick Children, Université de Paris, 75015, Paris, France.
  • Curtis W; Department of General Pediatrics and Pediatric Infectious Diseases, Necker-Enfants Malades University Hospital, Assistance Publique - Hôpitaux de Paris (AP-HP), Necker Hospital for Sick Children, Université de Paris, 75015, Paris, France.
  • Moulin F; M3C-Necker Enfants Malades, AP-HP, Paris, France.
  • Matczak S; Pediatric Emergency Department, Necker-Enfants Malades University Hospital, AP-HP, Université de Paris, Paris, France.
  • Leruez M; Pediatric Intensive Care Unit, Necker-Enfants Malades University Hospital, AP-HP, Université de Paris, Paris, France.
  • Casanova JL; Department of General Pediatrics and Pediatric Infectious Diseases, Necker-Enfants Malades University Hospital, Assistance Publique - Hôpitaux de Paris (AP-HP), Necker Hospital for Sick Children, Université de Paris, 75015, Paris, France.
  • Chalumeau M; Biodiversity and Epidemiology of Bacterial Pathogens, Institut Pasteur, Paris, France.
  • Taylor M; Virology Laboratory, Necker-Enfants Malades University Hospital, AP-HP, Université de Paris, Paris, France.
  • Allali S; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Imagine Institute, Pediatric Hematology and Immunology Unit, Necker-Enfants Malades University Hospital, AP-HP, Université de Paris, Paris, France.
J Clin Immunol ; 41(3): 526-535, 2021 04.
Article en En | MEDLINE | ID: mdl-33394320
BACKGROUND: An outbreak of multisystem inflammatory syndrome in children, including Kawasaki disease (KD), emerged during COVID-19 pandemic. We explored whether Kawasaki-like disease (KD), when associated with confirmed SARS-CoV-2 infection, has specific characteristics. METHODS: We included children and adolescents with KD criteria admitted in the department of general pediatrics of a university hospital in Paris, France, between January 1, 2018, and May 26, 2020. The incidence of KD was compared between the outbreak and a pre-outbreak control period (January 1, 2018, to April 25). Characteristics of patients with positive SARS-CoV-2 testing (KD-SARS-CoV-2) were compared to those of the pre-outbreak period (classic KD). RESULTS: A total of 30 and 59 children with KD were admitted during the outbreak and pre-outbreak periods, respectively (incidence ratio 13.2 [8.3-21.0]). During the outbreak, 23/30 (77%) children were diagnosed as KD-SARS-CoV-2. When compared with patients with classic KD, those with KD-SARS-CoV-2 were more frequently of sub-Saharan African ancestry (OR 4.4 [1.6-12.6]) and older (median 8.2 vs. 4.0 years, p < 0.001), had more often initial gastrointestinal (OR 84 [4.9-1456]) and neurological (OR 7.3 [1.9-27.7] manifestations, and shock syndrome (OR 13.7 [4.2-45.1]). They had significantly higher CRP and ferritin levels. Noticeably, they had more frequently myocarditis (OR 387 [38-3933]). CONCLUSIONS: Children and adolescents with KD-SARS-CoV-2 have specific features when compared with those with classic KD. These findings should raise awareness and facilitate the study of their pathogenesis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 1_ASSA2030 / 2_ODS3 / 4_TD Problema de salud: 1_doencas_nao_transmissiveis / 2_enfermedades_transmissibles / 2_muertes_prematuras_enfermedades_notrasmisibles / 4_pneumonia Asunto principal: SARS-CoV-2 / COVID-19 / Síndrome Mucocutáneo Linfonodular Tipo de estudio: Observational_studies Límite: Adolescent / Child / Female / Humans / Male País/Región como asunto: Europa Idioma: En Revista: J Clin Immunol Año: 2021 Tipo del documento: Article País de afiliación: Francia

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Contexto en salud: 1_ASSA2030 / 2_ODS3 / 4_TD Problema de salud: 1_doencas_nao_transmissiveis / 2_enfermedades_transmissibles / 2_muertes_prematuras_enfermedades_notrasmisibles / 4_pneumonia Asunto principal: SARS-CoV-2 / COVID-19 / Síndrome Mucocutáneo Linfonodular Tipo de estudio: Observational_studies Límite: Adolescent / Child / Female / Humans / Male País/Región como asunto: Europa Idioma: En Revista: J Clin Immunol Año: 2021 Tipo del documento: Article País de afiliación: Francia
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