The combination of dibenzazepine and a DOT1L inhibitor enables a stable maintenance of human naïve-state pluripotency in non-hypoxic conditions.

Isono, Wataru; Kawasaki, Tomoyuki; Ichida, Justin K; Ayabe, Takuya; Hiraike, Osamu; Umezawa, Akihiro; Akutsu, Hidenori

Isono, Wataru; Kawasaki, Tomoyuki; Ichida, Justin K; Ayabe, Takuya; Hiraike, Osamu; Umezawa, Akihiro; Akutsu, Hidenori.

Afiliación

Isono W; Center for Regenerative Medicine, National Center for Child Health and Development, 2-10-1 Okura, Setagaya, Tokyo, 157-8535, Japan.
Kawasaki T; Department of Obstetrics and Gynecology, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi, Tokyo, 173-8605, Japan.
Ichida JK; Center for Regenerative Medicine, National Center for Child Health and Development, 2-10-1 Okura, Setagaya, Tokyo, 157-8535, Japan.
Ayabe T; Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.
Hiraike O; Department of Obstetrics and Gynecology, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi, Tokyo, 173-8605, Japan.
Umezawa A; Department of Obstetrics and Gynaecology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8655, Japan.
Akutsu H; Center for Regenerative Medicine, National Center for Child Health and Development, 2-10-1 Okura, Setagaya, Tokyo, 157-8535, Japan.

Regen Ther ; 15: 161-168, 2020 Dec.

Article en En | MEDLINE | ID: mdl-33426214

Palabras clave

LIF; Naïve; Non-hypoxia; Pluripotent stem cell; Primed

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Regen Ther Año: 2020 Tipo del documento: Article País de afiliación: Japón

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