Synthesis and immunological evaluation of synthetic peptide based anti-SARS-CoV-2 vaccine candidates.
Chem Commun (Camb)
; 57(12): 1474-1477, 2021 Feb 15.
Article
en En
| MEDLINE
| ID: mdl-33443248
ABSTRACT
For prevention of the coronavirus disease 2019 caused by the novel coronavirus SARS-CoV-2, an effective vaccine is critical. Herein, several potential peptide epitopes from the spike protein of SARS-CoV-2 have been synthesized and covalently linked with the cross-reactive material (CRM197). Immunization of mice with the resulting conjugates induced high titers of IgG antibodies against the spike protein. Importantly, the post-immune sera effectively neutralized SARS-CoV-2 pseudovirus, suggesting the epitopes identified are protective, and these conjugates are promising leads for anti-SARS-CoV-2 vaccine development.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Vacunas de Subunidad
/
Vacunas contra la COVID-19
/
SARS-CoV-2
Idioma:
En
Revista:
Chem Commun (Camb)
Asunto de la revista:
QUIMICA
Año:
2021
Tipo del documento:
Article
País de afiliación:
China