Comparative Utilization and Efficacy of Thrombopoietin Receptor Agonists in Relapsed/Refractory Immune Thrombocytopenia.
Am J Ther
; 28(5): e525-e530, 2021 Jan 08.
Article
en En
| MEDLINE
| ID: mdl-33491968
ABSTRACT
BACKGROUND:
The thrombopoietin (TPO) agonists, eltrombopag and romiplostim, stimulate the production of platelets and offer an effective treatment option in relapsed/refractory immune thrombocytopenia (ITP). Recently published 2019 ITP guidelines recommend the TPO agonists as second-line therapy following corticosteroids; however, little data offer insights into comparative efficacy and tolerability. STUDY QUESTION Is there a difference in the efficacy between romiplostim and eltrombopag in relapsed/refractory ITP? STUDYDESIGN:
We conducted a single-center, retrospective chart review of patients with ITP treated with romiplostim or eltrombopag. MEASURES ANDOUTCOMES:
The primary objective was a sustained platelet response, defined as platelets greater than 50,000/µL in more than 66% of clinic visits over a 6-month period. Secondary objectives sought to evaluate response to and tolerability of TPO agonists.RESULTS:
The study included 107 consecutive patients, 67 (63%) on romiplostim and 40 (37%) on eltrombopag. Previous corticosteroids and rituximab were used in 95% and 50% of patients, respectively. There was no difference identified in platelet responses between the TPO-RAs, 72% romiplostim versus 65% eltrombopag (P = 0.520). In addition, no differences were identified in secondary measures of response.CONCLUSIONS:
In our experience with romiplostim and eltrombopag for ITP, we did not identify a difference in the efficacy of these agents. Further larger and prospective evaluations should be considered.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Púrpura Trombocitopénica Idiopática
/
Receptores de Trombopoyetina
Tipo de estudio:
Guideline
/
Observational_studies
Límite:
Humans
Idioma:
En
Revista:
Am J Ther
Asunto de la revista:
TERAPEUTICA
Año:
2021
Tipo del documento:
Article