Polyphenol-rich extract and fractions of Terminalia phaeocarpa Eichler possess hypoglycemic effect, reduce the release of cytokines, and inhibit lipase, &#945;-glucosidase, and &#945;-amilase enzymes.

Gomes, José Hugo de Sousa; Mbiakop, Ulrich Carlos; Oliveira, Renata Leite; Stehmann, João Renato; Pádua, Rodrigo Maia de; Cortes, Steyner F; Braga, Fernão Castro

Polyphenol-rich extract and fractions of Terminalia phaeocarpa Eichler possess hypoglycemic effect, reduce the release of cytokines, and inhibit lipase, α-glucosidase, and α-amilase enzymes.

Gomes, José Hugo de Sousa; Mbiakop, Ulrich Carlos; Oliveira, Renata Leite; Stehmann, João Renato; Pádua, Rodrigo Maia de; Cortes, Steyner F; Braga, Fernão Castro.

Afiliación

Gomes JHS; Department of Pharmaceutical Products, Faculty of Pharmacy, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, Belo Horizonte, Brazil.
Mbiakop UC; Department of Pharmacology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, Belo Horizonte, Brazil.
Oliveira RL; Department of Pharmaceutical Products, Faculty of Pharmacy, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, Belo Horizonte, Brazil.
Stehmann JR; Department of Botany, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, Belo Horizonte, Brazil.
Pádua RM; Department of Pharmaceutical Products, Faculty of Pharmacy, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, Belo Horizonte, Brazil.
Cortes SF; Department of Pharmacology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, Belo Horizonte, Brazil.
Braga FC; Department of Pharmaceutical Products, Faculty of Pharmacy, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, Belo Horizonte, Brazil. Electronic address: fernaobraga@farmacia.ufmg.br.

J Ethnopharmacol ; 271: 113847, 2021 May 10.

Article en En | MEDLINE | ID: mdl-33515684

Asunto(s)

Inhibidores Enzimáticos/farmacología; Hipoglucemiantes/farmacología; Lipasa/antagonistas & inhibidores; Extractos Vegetales/farmacología; Polifenoles/farmacología; Terminalia/química; alfa-Amilasas/antagonistas & inhibidores; Animales; Glucemia/efectos de los fármacos; Brasil; Citocinas/metabolismo; Inhibidores Enzimáticos/aislamiento & purificación; Inhibidores Enzimáticos/uso terapéutico; Humanos; Hipoglucemiantes/uso terapéutico; Masculino; Ratones; Extractos Vegetales/química; Extractos Vegetales/aislamiento & purificación; Extractos Vegetales/uso terapéutico; Hojas de la Planta/química; Polifenoles/análisis; Polifenoles/aislamiento & purificación; Polifenoles/uso terapéutico; Células THP-1; alfa-Glucosidasas/efectos de los fármacos; alfa-Glucosidasas/metabolismo

Palabras clave

Hypoglycaemic activity; In vitro assays; Oral starch tolerance test; Phenolics; Terminalia phaeocarpa; UHPLC-DAD-ESI-MS/MS analyses

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Extractos Vegetales / Terminalia / Inhibidores Enzimáticos / Alfa-Amilasas / Polifenoles / Hipoglucemiantes / Lipasa Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male País/Región como asunto: America do sul / Brasil Idioma: En Revista: J Ethnopharmacol Año: 2021 Tipo del documento: Article País de afiliación: Brasil

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