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Impact of prompt gamma emission of 44Sc on quantification in preclinical and clinical PET systems.
Rosar, Florian; Bohnenberger, Hendrik; Moon, Euy Sung; Rösch, Frank; Denig, Achim; Vincenz-Zörner, Daniel; Hoffmann, Manuela A; Khreish, Fadi; Ezziddin, Samer; Schreckenberger, Mathias; Buchholz, Hans-Georg; Schaefer-Schuler, Andrea.
Afiliación
  • Rosar F; Dep. of Nuclear Medicine, Saarland University, Homburg, Germany; Dep. of Nuclear Medicine, University of Mainz, Mainz, Germany. Electronic address: florian.rosar@uks.eu.
  • Bohnenberger H; Dep. of Nuclear Medicine, Saarland University, Homburg, Germany.
  • Moon ES; Dep. of Chemistry - TRIGA Site, University of Mainz, Mainz, Germany.
  • Rösch F; Dep. of Chemistry - TRIGA Site, University of Mainz, Mainz, Germany.
  • Denig A; Dep. of Nuclear Physics, University of Mainz, Mainz, Germany.
  • Vincenz-Zörner D; Mediso GmbH - Medical Imaging Systems, Münster, Germany.
  • Hoffmann MA; Dep. of Nuclear Medicine, University of Mainz, Mainz, Germany.
  • Khreish F; Dep. of Nuclear Medicine, Saarland University, Homburg, Germany.
  • Ezziddin S; Dep. of Nuclear Medicine, Saarland University, Homburg, Germany.
  • Schreckenberger M; Dep. of Nuclear Medicine, University of Mainz, Mainz, Germany.
  • Buchholz HG; Dep. of Nuclear Medicine, University of Mainz, Mainz, Germany.
  • Schaefer-Schuler A; Dep. of Nuclear Medicine, Saarland University, Homburg, Germany.
Appl Radiat Isot ; 170: 109599, 2021 Apr.
Article en En | MEDLINE | ID: mdl-33515928
ABSTRACT
44Sc is an increasingly investigated positron emitter for use in positron emission tomography (PET) imaging. However, 44Sc is a non-pure positron emitter, since prompt photons are co-emitted during the decay process. This study investigates coincidence energy spectra of 44Sc and its impact on PET quantification on a preclinical and clinical PET system in comparison with 18F. The raw data of the coincidence events revealed characteristic differences comparing the photon energy distribution of 44Sc and 18F. Due to prompt gamma emission of 44Sc, activity recovery is underestimated on PET systems. However, clinical PET imaging of 44Sc with acceptable quantitative accuracy appears feasible by using a single, constant correction factor.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Escandio / Tomografía de Emisión de Positrones / Rayos gamma Límite: Humans Idioma: En Revista: Appl Radiat Isot Asunto de la revista: MEDICINA NUCLEAR / SAUDE AMBIENTAL Año: 2021 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Escandio / Tomografía de Emisión de Positrones / Rayos gamma Límite: Humans Idioma: En Revista: Appl Radiat Isot Asunto de la revista: MEDICINA NUCLEAR / SAUDE AMBIENTAL Año: 2021 Tipo del documento: Article