Mechanogenomic coupling of lung tissue stiffness, EMT and coronavirus pathogenicity.
Curr Opin Solid State Mater Sci
; 25(1): 100874, 2021 Feb.
Article
en En
| MEDLINE
| ID: mdl-33519291
ABSTRACT
In this Current Opinion, we highlight the importance of the material properties of tissues and how alterations therein, which influence epithelial-to-mesenchymal transitions, represent an important layer of regulation in a number of diseases and potentially also play a critical role in host-pathogen interactions. In light of the current SARS-CoV-2 pandemic, we here highlight the possible role of lung tissue stiffening with ageing and how this might facilitate increased SARS-CoV-2 replication through matrix-stiffness dependent epithelial-to-mesenchymal transitions of the lung epithelium. This emphasizes the need for integrating material properties of tissues in drug discovery programs.
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1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Curr Opin Solid State Mater Sci
Año:
2021
Tipo del documento:
Article
País de afiliación:
Suiza