Disruption of CCR5 signaling to treat COVID-19-associated cytokine storm: Case series of four critically ill patients treated with leronlimab.
J Transl Autoimmun
; 4: 100083, 2021.
Article
en En
| MEDLINE
| ID: mdl-33521616
ACE2, angiotensin-converting enzyme 2; ALT, alanine aminotransferase; ARDS, acute respiratory distress syndrome; AST, aspartate aminotransferase; Acute respiratory distress syndrome (ARDS); BID, bis in die (twice a day); CCL2, chemokine CC motif ligand 2; CCL3, chemokine CC motif ligand 3; CCL4, chemokine CC motif ligand 4; CCL5, chemokine CC motif ligand 5; CCR1, CC chemokine receptor type 1; CCR5, CC chemokine receptor type 5; CDC, Centers for Disease Control; CK, creatine kinase; COPD, chronic obstructive pulmonary disease; COVID-19, coronavirus disease 2019; CRP, C-reactive protein; CXCL10, chemokine C-X-C motif ligand 10; CXCL2, chemokine C-X-C motif ligand 2; Coronavirus disease 2019 (COVID-19); DPP4, dipeptidyl peptidase-4; DVT, deep vein thrombosis; EDTA, ethylenediaminetetraacetic acid; FDA, Food and Drug Administration; Fi02, fraction of inspired oxygen, IgG4; Hydroxychloroquine, HLH; Leronlimab (PRO 140); Middle East respiratory syndrome coronavirus, MIG; National Early Warning Score, NK; RO, receptor occupancy; RTPCR, reverse transcriptase polymerase chain reaction; SARS-CoV, severe acute respiratory syndrome coronavirus; SARS-CoV-2; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; T-reg RO, regulatory T cells receptor occupancy; TGF- α, transforming growth factor alpha; TNF-α, tumor necrosis factor alpha; TNF-ß, tumor necrosis factor beta; Tregs, regulatory T cells; VEGF-A, vascular endothelial growth factor A; WBC, white blood cell; WHO, World Health Organization; eIND, emergency investigational new drug application; hemophagocytic lymphohistiocytosis, HTN; hypertension, ICU; immunoglobulin G4, HCQ; intensive care unit, IL-1ß; interferon gamma, IL-6; interferon gamma-inducible protein (IP) 10 or CXCL10, LOA; interleukin 1 beta, IFN-Æ´; interleukin 6, IP-10; letter of authorization, MCP; macrophage Inflammatory Proteins 1-alpha, MIP-1ß; macrophage Inflammatory Proteins 1-beta, N/A; macrophage colony stimulating factor, MDC (CCL22); macrophage colony-stimulating factor encoded by the CCL22 gene, MERS-CoV; monocyte chemoattractant protein, M-CSF; monokine induced by IFN-γ (interferon gamma), MIP-1α; natural killer, OSA; not applicable, NEWS2; obstructive sleep apnea, PDGF-AA; per os (taken by mouth), RANTES; platelet-derived growth factor AA, PDGF-AA/BB; platelet-derived growth factor AA/BB, PEEP; positive end-expiratory pressure, PNA; pulmonary nodular amyloidosis, po; regulated on activation, normal T expressed and secreted (also known as CCL5)
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Contexto en salud:
2_ODS3
/
4_TD
/
6_ODS3_enfermedades_notrasmisibles
Problema de salud:
2_cobertura_universal
/
4_covid_19
/
6_chronic_obstructive_pulmonary_disease
/
6_venous_thromboembolic_disease
Tipo de estudio:
Risk_factors_studies
Idioma:
En
Revista:
J Transl Autoimmun
Año:
2021
Tipo del documento:
Article
País de afiliación:
Estados Unidos